About Us
ITSIBIO »We have partnered with several renowned companies to provide our clients with access to QuantiGene products, custom ELISA kits, DNA/protein arrays, and innovative DNA storage solutions at competitive prices.
Who We Serve
Our team of senior scientists has extensive experience and manages every project with discretion and professionalism. They frequently communicate with the customer using cutting-edge web-based tools. The staff’s commitment and adaptability are unmatched, and ITSIBIO solution-focused strategy ensures that all stakeholders receive the highest return on investment.
We also collaborate with researchers from academic medical centers, study institutes, biotechnology firms, pharmaceutical firms, and universities to initiate exposure to various technological advancements. Contact us for more information.
Our Mission
Corporate Values
ITSIBIO adheres to the highest standards of education, quality assurance, quality control, and safety, maintaining strict compliance with Good Laboratory Practices (GLP). Our work culture promotes innovation, dedication, hard work, and diligence among our staff, and we consistently reward our employees for their contributions.
Our Projects
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- Microbio Forensic for BioDefence – Indiana University of Pennsylvania, Indiana, PA, USA.
- Application of proteomics to elucidate the effects of caloric restriction and radiation on breast cancer in mice – Thomas Jefferson University, Philadelphia, PA, USA.
- Proteomic identification of Target for Breast Cancer Therapy – Windber Research Institute, Windber, PA USA.
- Proteomics studies on the mechanisms of blast-induced traumatic brain injury using the in-vitro model system – Walter Reed Army Institute of Research 503 Robert Grant Ave Silver Spring, MD 20910
- Aging quantification of mhc-ii alpha e peptide in 3 and 22 months mouse-project I – Albert Einstein College of Medicine, NY, USA.
- LC-MS/MS Analysis of Serum Depleted Noninfected (EC) and VL-Infected (VL) – Infectious Disease Research Institute, Seattle, WA, USA.
- Aging quantification of mhc-ii alpha e peptide in 3 and 22 months mouse-project II – Albert Einstein College of Medicine, Bronx, NY, USA.
- Studies on the mechanisms of blast-induced traumatic brain injury using an in-vitro model systems – University of Texas Southwestern Medical Center, Dallas, TX, USA.
- Proteomics of SMOC-Associated proteins – U.S. Food and Drug Administration, CBE Bethesda, MD, USA.
- PTM analysis on tp2 – CHROMATIN BIOLOGY LAB, Molecular Biology and Genetic Unit, JNCASR, Bangalore, India.
- Proteomics Study of Lung Cells – University of Texas at Dallas, Dallas, TX, USA.
- Studies on the mechanisms of blast-induced traumatic brain injury using the in-vitro model system – Walter Reed Army Institute of Research, Silver Spring, MD, USA.
- LC-MS/MS Analysis of Serum Depleted Noninfected (EC) and VL-Infected (VL) – Infectious Disease Research Institute, Seattle, WA, USA.
- Aging quantification of mhc-ii alpha e peptide in 3 and 22 months mouse-project – Albert Einstein College of Medicine, Bronx, NY, USA.
- LC-MS/MS Analysis of Serum Depleted Noninfected (EC) and VL-Infected (VL) – Infectious Disease Research Institute, Seattle, WA, USA.
- Identification of stat2 dependent inflammatory mediators – NCI-Frederick, Frederick, MD, USA.
- Studies on the mechanisms of blast-induced traumatic brain injury using an in-vitro model system – University of Texas Southwestern Medical Center, Dallas, TX, USA.
- PTM ANALYSIS On HILS1 – CHROMATIN BIOLOGY LAB, Molecular Biology and Genetic Unit, JNCASR Bangalore, India.
- Protein identification from tryptic digestion – Albert Einstein College of Medicine, Bronx, NY, USA.
- LC-MS/MS Analysis of Purified LdPDI Protein – Infectious Disease Research Institute, Seattle, WA, USA.
- Identification of Trypanosoma brucei Sumoylated proteins – Avenida General Paz 5445 INTI-Edificio 19, Bueno Aires, Argentina.
Publications
Browse through our comprehensive list of scientific publications and research papers our team of experts produced.
42. Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2.
Miyazawa, Masaki 2, Alexander R. Bogdan, Yoshiaki Tsuji 3. Cell Chemical Biology, November 15, 2018, Volume 26, Issue 1, 85 – 97.e4. doi: 10.1016/j.chembiol.2018.10.009
41. Identification of Protein Markers in Patients Infected with Plasmodium knowlesi, Plasmodium falciparum and Plasmodium vivax.
Alan Kang-Wai Mu, Int J Mol Sci. 2014 Nov 3;15(11):19952-61. doi: 10.3390/ijms151119952.
40. AMP-activated protein kinase mediates insulin-like and lipo-mobilising effects of β-glucan-rich polysaccharides isolated from Pleurotus sajor-caju (Fr.), Singer mushroom, in 3T3-L1 cells.
39. A colorimetric method for monitoring tryptic digestion prior to shotgun proteomics.
Somiari RI, Renganathan K, Russell S, Wolfe S, Mayko F, Somiari SB.Int J Proteomics. 2014;2014:125482. doi: 10.1155/2014/125482.
38. Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells.
Pastwa E, Poplawski T, Lewandowska U, Somiari SB, Blasiak J, Somiari RI. Int J Biochem Cell Biol. 2014 Aug;53:423-31.
37. DNA aptamers against exon v10 of CD44 inhibit breast cancer cell migration.
Iida J, Clancy R, Dorchak J, Somiari RI, Somiari S, Cutler ML, Mural RJ, Shriver CD. PLoS One. 2014 Feb 19;9(2):e88712.
36. A Novel Type of Hemocytes Localizing Melanization with High-Spreading Behavior in Mythimna Separata.
Yoshiaki Kato, Tatsuhiro Yoshida, Ken Miura, Toshiharu Tanaka, Yutaka Nakamatsu, Masanori Ochiai, Archives of Insect Biochemistry and Physiology 2014 Jul DOI: 10.1002/arch.21173
35. Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses.
H. C. Steen, S. Nogusa, R. J. Thapa, S.H. Basagoudanavar, A. Gill, S. Merali, C. A. Barrero, S. Balachandran, A. M. Gamero, The Journal of Biological Chemistry
34. COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.
T. A. Packard, Q.Z. Li, G.P. Cosgrove, R.P. Bowler, J.C. Cambier Immunol Res (2013) 55:48–57, September 2012. Springer Science+Business Media
33. Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase.
P. Arun, R. Abu-Taleb, S. Oguntayo, Y. Wang, M. Valiyaveettil, J. Long, M.P. Nambiar Journal of Neurotrauma
32. Modulation of hearing related proteins in the brain and inner ear following repeated blast exposures.
P. Arun, M. Valiyaveettil1, L. Biggemann, Y. Alamneh, Y. Wei, S. Oguntayo, Y. Wang, J.B. Long, M.P. Nambiar1 … Interventional Medicine & Applied Science vol.4 2012 October 1
31. Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen.
Y Miyano, S Tsukuda, I Sakimoto, R Takeuchi, Satomi Shimuraa, N Takahashia,T Kusayanagia,Y Takakusagia … Journal of Proteomics-Elsevier Inc. 2012 May 15
30. Beta-Catenin Phosphorylated at Threonine 120 Antagonizes Generation of Active Beta-Catenin by Spatial Localization in trans-Golgi Network.
Cheng Du1, Chuanyou Zhang1, Zhuo Li1, Md. Helal Uddin Biswas1, K. C. Balaji2.PLos ONE. 2012 April 12; Volume 7, Issue 4
29. How the Surface Nanostructure of Polyethylene Affects Protein Assembly and Orientation.
James D. Bortner, Arunangshu Das, Todd M. Umstead, Williard M. Freeman, Richard Somiari, Cesar Aliaga, David S. Phelps, . ACS Nano. 03/2011; 5(4).
28. Method for releasing reducing Glycan by Ammonium Salt.
Nishimura, Shin-ichiro, Miura, Yoshiaki. Free Patents online. 2011 November 10, patent:20110275108
27. Senescence Marker Protein 30 (SMP30) Expression in Eukaryotic Cells: Existence of Multiple Species and Membrane Localization.
Peethambaran Arun, Vineela Aleti, Kalpana Parikh, Veeraswamy Manne, Nageswararao Chilukuri. PLos ONE. 2011 February; Volume 6, Issue 2
26. The effect of selenium enrichment on baker’s yeast proteome.
K. El-Bayoumy, A. Dasa, S. Russell, S. Wolfe, R. Jordan, K. Renganathan, T.P. Loughranb, R. Somiari. Journal of Proteomics-Elsevier Inc. 2011 October 21;.10.1016
25. Repeated Blast Exposures Lead to Changes in Hearing Related Gene Expression in Mice Brain.
P. Arun, Y. Wang, Y. Wei, S. Oguntayo, L. Biggemann, M. P. Nambiar. RTA.nato.Int. 2011.
24. Effect of Immunohistochemistry on Molecular Analysis of Tissue Samples.
M. A. Tangrea, S. Mukherjee, B. Gao, S P. Markey, Q. Du, M. Armani M. S. Kreitman, A.M. Rosenberg, B.S. Wallis, F. C. Eberle, F.C. Duncan, J.C. Hanson, R.F. Chuaqui, J.Rodriguez-Canales, M.R. Emmert-Buck Journal of Histochemistry & Cytochemistry. 2011 February 24.
23. Differential profile analysis of urinary cytokines in patients with overactive bladder.
G.Ghoniem., N. Faruqui., M. Elmissiry. Int. Urogynecol J Springer. 2011 April13; 22:953-961
22. Polyphenols Activate Nrf2 in Astrocytes Via H2O2, Semi-Quinones and Quinones.
H. Erlanka, A. Elmanna, R. Kohenb, J. Kanner Free Radical Biology and Medicine-Elsevier Inc. 2011 September 28;10.1016
21. Sample Preparation for 2D Electrophoresis and CE-Based Proteomics .
J. M. Nagy, A. Lipka, F. Pereira, N. Marlin, S. Hassard Springer Science+Buisness Media (google book) 2011.
20. STR Analysis of Human DNA Samples After Dry-State Ambient Temperature Storage in Geneplates.
Richard I. Somiari, E. Adebiyi, L. Ukachukwu, I. Mba, F. A. Anthony, A. I. Onuaha, M.Brainard, S.Lubert, C. Larson, S. Russell, N. Bharathan, S.B. Somiari. The Open Forensic Science Journal, 2011, 4, 30-35, November 23, 2011.
19. Selenium-Responsive Proteins in the Sera of Selenium-Enriched Yeast-Supplemented Healthy American and Caucasian Men.
R. Sinha., I. Sinha., N. Facompreruqui., M. Elmissiry. Journal of Biomedical Science. 2009 September;35(3):559-67.
18. Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis.
Bortner JD Jr, Das A, Umstead TM, Freeman WM, Somiari R, Aliaga C, Phelps DS, El-Bayoumy K. J Proteome Res. 2009 Aug;8(8):4050-61. doi: 10.1021/pr900406g
17. Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma.
16. Proteomics of rat prostate lobes treated with 2-N-Hydroxylamino-1-methyl-6-phenylimidazo [4,5-b] pyridine, 5alpha-dihydrotestosterone, individually and in combination.
Boyiri, T., Somiari, RI., Russell, S., EL-Bayoumy, K. Int. J Oncol. 2009 Sep;35(3):559-67
15. Circulating MMP2 and MMP9 in breast cancer – potential role in classification of patients into low risk, benign disease and breast cancer categories.
Somiari, S., Somiari, RI., Heckman, C., Olsen, C., Jordan R., Russell, S., Shriver, C., Cancer. 2006 Sep15;119(6):1403-11.
14. Plasma activity of matrix metalloproteinase 2 and 9 in breast disease.
Somiari, S., Craig, S., Heckman, C., Jordan R., Arciero, C., Hooke, J., Olsen, C., Garguilo, G., Somiari, RI. Cancer Lett. 2006 Feb20;223(1):98-107
13. Proteomics of breast carcinoma.
Somiari RI, Somiari S, Russell S, Shriver CD. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 5;815(1-2):215-25.
12. Difference gel Electrophoresis in a High throughput Research Environment.
Somiari RI. Russell S, Somiari SB, Sullivan AG, Ellsworth, DL, Brzeski, H, Shriver, CD In Walker J. (Editor) The Proteomics Protocols Handbook. Humana Press Inc., NJ, USA. 2005;pp. 223 – 237.
11. Laser assisted microdissection in proteomic analyses.
Ellsworth DL, Russell S, Deyarmin B, Sullivan A, Brzeski H, Somiari RI, Shriver CD . In Walker J. (Editor) The Proteomics Protocols Handbook. Humana Press Inc., NJ, USA. 2005;pp. 59-66.
10. Large-format two dimensional polyacrylamide gel electrophoresis.
Brzeski, H., Sullivan, A., Somiari, R., & Shriver, C. In Walker J. (Editor) The Proteomics Protocols Handbook. Humana Press Inc., NJ, USA. 2005;pp. 119-132.
9. Serum or Plasma Sample Preparation for Two-Dimensional Gel Electrophoresis.
Sullivan, A., Brzeski, H., Somiari, R., & Shriver, C. In Walker J. (Editor) The Proteomics Protocols Handbook. Humana Press Inc., NJ, USA. 2005; pp. 49-54.
8. Anti-Sm and anti-RNP antibodies.
P. MIGLIORINI, C. BALDINI, V. ROCCHI, & S. BOMBARDIERI Autoimmunity, February 2005; 38(1): 47–54
7. Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization.
Somiari SB, Shriver CD, He J, Parikh K, Jordan R, Hooke J, Hu H, Deyarmin B, Lubert S, Malicki L, Heckman C, Somiari RI. Cancer Genet Cytogenet. 2004 Dec;155(2):108-18.
6. Albumin depletion method for improved plasma glycoprotein analysis by two-dimensional difference gel electrophoresis.
Brzeski H, Katenhusen R, Sullivan A, Russell S, George A, Somiari RI, Shriver C. Biotechniques 2003 Dec;35(6):1128-32.
5. High-throughput proteomic analysis of human infiltrating ductal carcinoma of the breast.
Somiari RI, Sullivan A, Russell S, Somiari S, Hu H, Jordan R, George A, Katenhusen R, Buchowiecka A, Arciero C, Brzeski H, Hooke J, Shriver C. Proteomics. 2003 Oct;3(10):1863-73.
4. High-throughput loss of heterozygosity mapping in 26 commonly deleted regions in breast cancer.
Ellsworth RE, Ellsworth DL, Lubert SM, Hooke J, Somiari RI, Shriver CD. Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):915-9
3. Laser capture microdissection of paraffin-embedded tissues.
Ellsworth DL, Shriver CD, Ellsworth RE, Deyarmin B, Somiari RI. Biotechniques. 2003 Jan;34(1):42-4, 46
2. Heat shock cognate-70 gene expression decreases during normal aging of the primate retina.
Bernstein S. L, Liu, M-H, Hansen, B. C. & Somiari R.I.IOVS 2000 Sep;41 (10): 2857-62.
1. A high-density differential screening strategy for identification of fovea genes with altered expression in the retina during aging.
R. I. Somiari, P. Wong, S. L. Bernstein. Biotechnology Techniques 1999 13 (9): 577-581
